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    Unleashing the potential of cyclodextrin-based nanosponges in management of colon cancer: A review

    • Popat Mohite
    • Shubham Munde
    • Anil Pawar
    • Sudarshan Singh


    Abstract

    Colon cancer ranked second in terms of incidence in the world, yearly it shows an increase in the tendency of mortality. It is estimated that by the year 2035 total number of deaths will increase by 75 %. The treatment of cancer includes surgery, radiation therapy, and chemotherapy, however, they are limited due to their targeted therapeutic potential and side effects. In the case of a conventional drug delivery system, it is desired that the drug delivery system should be able to protect the therapeutic from degradation and safety target to the desired site. Cyclodextrin-based nanosponges (NS) are a versatile platform for colon cancer treatment, surpassing the limitations of conventional drug delivery systems. Nanosponge offers several advantages such as improved drug solubility, enhanced stability, targeted delivery, and potential for combination therapy due to its highly cross-linked structure. The fabrication of NS includes the use of biopolymers for the controlled release of drugs from pores through diffusion. These pores can efficiently encapsulate a wide range of therapeutic agents, enabling regulated release, and addressing challenges associated with poor solubility and limited stability of drugs used in the management of colon cancer. Additionally, their functionalization enables targeted drug delivery to colon cancer cells, minimizing off-target effects. Though several benefits are associated with NS, further research is needed to address regulatory considerations and scale up NS for translation into clinical practice. Overall, cyclodextrin-based NS holds promise in revolutionizing colon cancer treatment and improving patient outcomes.

    Keywords: Cyclodextrin Colon cancer Drug delivery Improved Solubility Nanosponges
    Section

    References

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    Unleashing the potential of cyclodextrin-based nanosponges in management of colon cancer: A review. (2024). Nanofabrication, 9. https://doi.org/10.37819/nanofab.9.1823
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