Skip to main content Skip to main navigation menu Skip to site footer
  • \
    Start Submission Become a Reviewer

    Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles

    • Remya Prabhavathi Neelakandan
    • Divya R
    • Damodharan N


    Abstract

    This study aimed to create and describe mucoadhesive nimodipine solid lipid nanoparticles as buccal tablets by altering the amounts of three polymers: Carbopol 934, Hydroxypropyl methylcellulose and Hydroxyethyl cellulose. The Nimodipine-loaded solid lipid nanoparticles (SLN) were formulated by high shear homogenization and ultrasonication process using palmitic and stearic acid as the lipid matrix and Tween-80 as the surfactant. The swelling properties of all formulations were investigated, and it was discovered that all formulations have a good swelling index at 6 hours. The surface pH of each batch varied between 5.6 and 6.1. The mucoadhesive strengths (15.3-29.5 g) varied with polymer concentrations, particularly Carbopol 934. All batches had considerably different dissolution profiles, ranging from a maximum release of 89.08% (at 8h in batch NT3) to a minimum release of 80.32% (at 8h in batch NT2). SLN formulations had the best results in both Entrapment efficiency and In-vitro drug release, showing that SLN may be a promising delivery strategy for improving Nimodipine release.

    Keywords: Nimodipine Mucoadhesive buccal tablets Carbopol 934 Hydroxypropyl methylcellulose Hydroxyethyl cellulose Solid lipid nanoparticles
    Section

    References

    1. Akter, M., Banik, S., & Hossain, M. S. (2012). In vitro evaluation of oral extended release drug delivery system for metoprolol succinate using Kollidon SR. Journal of Applied Pharmaceutical Science, 2(5), 188–192. https://doi.org/10.7324/JAPS.2012.2539
    2. Andrews, G. P., Laverty, T. P., & Jones, D. S. (2009). Mucoadhesive polymeric platforms for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 71(3), 505–518. https://doi.org/10.1016/J.EJPB.2008.09.028
    3. Arabi, M., Mortazavi, S. A., Jafariazar, Z., Farhadnejad, H., Haris, G. A., & Fatahi, Y. (2020). Fabrication and in-vitro evaluation of buccal mucoadhesive tablet of meloxicam. Iranian Journal of Pharmaceutical Research, 19(3), 63–76. https://doi.org/10.22037/ijpr.2019.111820.13378
    4. Bernkop-Schnürch, A. (2005). Mucoadhesive systems in oral drug delivery. Drug Discovery Today: Technologies, 2(1), 83–87. https://doi.org/10.1016/J.DDTEC.2005.05.001
    5. Boddupalli, B. M., Mohammed, Z. N. K., Nath A., R., & Banji, D. (2010). Mucoadhesive drug delivery system: An overview. Journal of Advanced Pharmaceutical Technology and Research, 1(4), 381–387. https://doi.org/10.4103/0110-5558.76436
    6. Chalikwar, S. S., Belgamwar, V. S., Talele, V. R., Surana, S. J., & Patil, M. U. (2012). Formulation and evaluation of Nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system. Colloids and Surfaces B: Biointerfaces, 97, 109–116. https://doi.org/10.1016/j.colsurfb.2012.04.027
    7. Drug, M., & Systems, D. (1993). M a Rosa Jim&nez-Castellanos2, Hussein Zial and C. T. Rhodes’ Department of Pharmaceutics, University of Rhocle Island, Kingston, RI 02881. 19, 143–194.
    8. Harris, D., & Robinson, J. R. (1992). Drug delivery via the mucous membranes of the oral cavity. Journal of Pharmaceutical Sciences, 81(1), 1–10. https://doi.org/10.1002/jps.2600810102
    9. Henriksen, I., Green, K. L., Smart, J. D., Smistad, G., & Karlsen, J. (1996). Bioadhesion of hydrated chitosans: An in vitro and in vivo study. International Journal of Pharmaceutics, 145(1–2), 231–240. https://doi.org/10.1016/S0378-5173(96)04776-X
    10. Hosny, K. M., Banjar, Z. M., Hariri, A. H., & Hassan, A. H. (2015). Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia. Drug Design, Development and Therapy, 9, 313–320. https://doi.org/10.2147/DDDT.S77702
    11. Huang, Y., Leobandung, W., Foss, A., & Peppas, N. A. (2000). Molecular aspects of muco- and bioadhesion:: Tethered structures and site-specific surfaces. Journal of Controlled Release, 65(1–2), 63–71. https://doi.org/10.1016/S0168-3659(99)00233-3
    12. Kianfar, F., Antonijevic, M. D., Chowdhry, B. Z., & Boateng, J. S. (2011). Formulation Development of a Carrageenan Based Delivery System for Buccal Drug Delivery Using Ibuprofen as a Model Drug. Journal of Biomaterials and Nanobiotechnology, 02(05), 582–595. https://doi.org/10.4236/jbnb.2011.225070
    13. Lin, C. H., Chen, C. H., Lin, Z. C., & Fang, J. Y. (2017). Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. Journal of Food and Drug Analysis, 25(2), 219–234. https://doi.org/10.1016/j.jfda.2017.02.001
    14. Mehnert, W., & Mäder, K. (2001). Solid lipid nanoparticles: Production, characterization and applications. Advanced Drug Delivery Reviews, 47(2–3), 165–196. https://doi.org/10.1016/S0169-409X(01)00105-3
    15. Mishra, V., Bansal, K. K., Verma, A., Yadav, N., Thakur, S., Sudhakar, K., & Rosenholm, J. M. (2018). Solid lipid nanoparticles: Emerging colloidal nano drug delivery systems. Pharmaceutics, 10(4), 1–21. https://doi.org/10.3390/pharmaceutics10040191
    16. Müller, R. H., Mäder, K., & Gohla, S. (2000). Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics, 50(1), 161–177. https://doi.org/10.1016/S0939-6411(00)00087-4
    17. Patel, V. F., Liu, F., & Brown, M. B. (2011). Advances in oral transmucosal drug delivery. Journal of Controlled Release, 153(2), 106–116. https://doi.org/10.1016/J.JCONREL.2011.01.027
    18. Salamat-Miller, N., Chittchang, M., & Johnston, T. P. (2005). The use of mucoadhesive polymers in buccal drug delivery. Advanced Drug Delivery Reviews, 57(11), 1666–1691. https://doi.org/10.1016/j.addr.2005.07.003
    19. Shaikh, R., Raj Singh, T., Garland, M., Woolfson, A., & Donnelly, R. (2011). Mucoadhesive drug delivery systems. Journal of Pharmacy and Bioallied Sciences, 3(1), 89–100. https://doi.org/10.4103/0975-7406.76478
    20. Tzanova, M. M., Hagesaether, E., & Tho, I. (2021). Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy. International Journal of Pharmaceutics, 592, 120100. https://doi.org/10.1016/J.IJPHARM.2020.120100
    21. Wong, C. F., Yuen, K. H., & Peh, K. K. (1999). Formulation and evaluation of controlled release Eudragit buccal patches. International Journal of Pharmaceutics, 178(1), 11–22. https://doi.org/10.1016/S0378-5173(98)00342-1
    22. Woodley, J. (2001). Bioadhesion. Clinical Pharmacokinetics, 40(2), 77–84. https://doi.org/10.2165/00003088-200140020-00001
    23. Yedurkar, P., Dhiman, M. K., Petkar, K., & Sawant, K. (2012). Mucoadhesive bilayer buccal tablet of carvedilol-loaded chitosan microspheres: In vitro, pharmacokinetic and pharmacodynamic investigations. Journal of Microencapsulation, 29(2), 126–137. https://doi.org/10.3109/02652048.2011.630109
    24. Yehia, S. A., El-Gazayerly, O. N., & Basalious, E. B. (2008). Design and in vitro/in vivo evaluation of novel mucoadhesive buccal discs of an antifungal drug: Relationship between swelling, erosion, and drug release. AAPS PharmSciTech, 9(4), 1207–1217. https://doi.org/10.1208/s12249-008-9166-1
    25. Zewail, M. B., F.Asaad, G., Swellam, S. M., Abd-allah, S. M., K.Hosny, S., Sallah, S. K., E.Eissa, J., S.Mohamed, S., & El-Dakroury, W. A. (2022). Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation. International Journal of Pharmaceutics, 624, 122006. https://doi.org/10.1016/J.IJPHARM.2022.122006

    How to Cite

    Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles. (2023). Nanofabrication, 8. https://doi.org/10.37819/nanofab.008.296
    ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
    Download Citation
    Endnote/Zotero/Mendeley (RIS) BibTeX

    How to Cite

    Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles. (2023). Nanofabrication, 8. https://doi.org/10.37819/nanofab.008.296

    HTML
    589

    Total
    1281

    Share

    Search Panel

    Remya Prabhavathi Neelakandan
    Google Scholar
    Pubmed
    JDMFS Journal

    Divya R
    Google Scholar
    Pubmed
    JDMFS Journal

    Damodharan N
    Google Scholar
    Pubmed
    JDMFS Journal

    Downloads

    Article Details

    Most Read This Month

    License

    Copyright (c) 2023 Remya Prabhavathi Neelakandan, Divya R, Damodharan N

    Creative Commons License

    This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

    Copyright © 2023 EurAsia Academic Publishing Group. All rights reserved