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Microglia Heterogeneity: A Single-cell Concerto

  • Leilei Wang
  • Haoran Wu
  • Shanshan Zhang
  • Dingxian He
  • Yi Chen
  • Jingxin Xue
  • Linya You
  • Qiong Liu
  • Wensheng Li

Abstract

Microglia are tissue-resident macrophages of the central nervous system (CNS) that play crucial roles in development, homeostasis, and response to perturbation. Microglia react to the surrounding environment in a context-dependent manner. However, research on microglial heterogeneity is limited, given the lack of high-resolution and high-sensitivity methods. Recent studies have demonstrated the heterogeneity of microglia on a spatial-temporal scale, benefiting from the advancement of single-cell technologies. Here, we review the current knowledge about microglial diversity during physiological and pathological conditions in humans and mice.

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How to Cite

Wang, L. ., H. . Wu, S. . Zhang, D. . He, Y. . Chen, J. . Xue, L. . You, Q. . Liu, and W. . Li. “Microglia Heterogeneity: A Single-Cell Concerto”. Human Brain, vol. 1, no. 1, July 2022, doi:10.37819/hb.001.001.0208.

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Copyright (c) 2022 Leilei Wang, Haoran Wu, Shanshan Zhang, Dingxian He, Yi Chen , Jingxin Xue, Linya You, Qiong Liu, Wensheng Li

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