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Microglia Heterogeneity: A Single-cell Concerto

  • Leilei Wang
  • Haoran Wu
  • Shanshan Zhang
  • Dingxian He
  • Yi Chen
  • Jingxin Xue
  • Linya You
  • Qiong Liu
  • Wensheng Li


Microglia are tissue-resident macrophages of the central nervous system (CNS) that play crucial roles in development, homeostasis, and response to perturbation. Microglia react to the surrounding environment in a context-dependent manner. However, research on microglial heterogeneity is limited, given the lack of high-resolution and high-sensitivity methods. Recent studies have demonstrated the heterogeneity of microglia on a spatial-temporal scale, benefiting from the advancement of single-cell technologies. Here, we review the current knowledge about microglial diversity during physiological and pathological conditions in humans and mice.



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How to Cite

Wang, Leilei, et al. “Microglia Heterogeneity: A Single-Cell Concerto”. Human Brain, vol. 1, no. 1, July 2022, pp. 77–91, doi:10.37819/hb.001.001.0208.


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