Role and mechanism of autophagy in the occurrence and development of meningothelial meningioma
Abstract
This paper aims to investigate the role and mechanism of autophagy in meningioma. A total of 182 meningiomas which diagnosed in the ultrastructural pathology department of Beijing Neurosurgical Institute, Beijing Tiantan Hospital from 1993 to 2021. Light microscope, electron microscope, western blotting and immunohistochemical staining were used. 182 meningiomas, 104 males and 78 females. There were 174 WHO grade 1 benign meningiomas, including 62 meningothelial types, 39 fibrous type, 58 transitional types, 15 angiomatous types, 6 WHO grade 2 cases, including 4 clear cell types and 2 atypical types, 2 WHO grade 3 anaplastic types. Transmission electron microscopy (TEM) showed that the incidence of autophagosomes as a high expression in 27 cases, most of which were meningothelial meningiomas. Immunohistochemical markers EMA, PR, Vimentin, SSTR-2, Ki67, and CD34 were positively expressed in most of the tumors, GFAP, S-100, desmin, C-erbB-2 expression were negative. Western blotting was used to detect the up-regulated proteins of LC3, Beclin1, and down-regulated proteins of Bax, Caspase3, mTOR, PI3K, Akt, S6 and 4EBP1in meningothelial meningiomas compared with the none –meningothelial control group.Autophagy is induced by down-regulating PI3K/Akt/mTOR signaling pathway molecules in meningothelial meningiomas, which can inhibit tumor apoptosis and promote tumorigenesis.
Section
References
- Vernooij Meike W., Ikram M Arfan., Tanghe Hervé L., Vincent Arnaud J P E., Hofman Albert., Krestin Gabriel P., Niessen Wiro J., Breteler Monique M B., van der Lugt Aad.(2007). Incidental findings on brain MRI in the general population. N Engl J Med, 357(18), 1821-8. doi:10.1056/NEJMoa070972
- Goldbrunner Roland., Stavrinou Pantelis., Jenkinson Michael D., Sahm Felix., Mawrin Christian., Weber Damien C., Preusser Matthias., Minniti Giuseppe., Lund-Johansen Morten., Lefranc Florence., Houdart Emanuel., Sallabanda Kita., Le Rhun Emilie., Nieuwenhuizen David., Tabatabai Ghazaleh., Soffietti Riccardo., Weller Michael.(2021). EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol, 23(11), 1821-1834. doi:10.1093/neuonc/noab150
- Huang Raymond Y., Bi Wenya Linda., Griffith Brent., Kaufmann Timothy J., la Fougère Christian., Schmidt Nils Ole., Tonn Jöerg C., Vogelbaum Michael A., Wen Patrick Y., Aldape Kenneth., Nassiri Farshad., Zadeh Gelareh., Dunn Ian F., International Consortium on Meningiomas.(2019). Imaging and diagnostic advances for intracranial meningiomas. Neuro Oncol, 21(null), i44-i61. doi:10.1093/neuonc/noy143
- Fountain Daniel M., Soon Wai Cheong., Matys Tomasz., Guilfoyle Mathew R., Kirollos Ramez., Santarius Thomas.(2017). Volumetric growth rates of meningioma and its correlation with histological diagnosis and clinical outcome: a systematic review. Acta Neurochir (Wien), 159(3), 435-445. doi:10.1007/s00701-016-3071-2
- Nakasu Satoshi., Nakasu Yoko.(2020). Natural History of Meningiomas: Review with Meta-analyses. Neurol Med Chir (Tokyo), 60(3), 109-120. doi:10.2176/nmc.ra.2019-0213
- Siempis Timoleon., Tsakiris Charalampos., Alexiou George A., Xydis Vassileios G., Voulgaris Spyridon., Argyropoulou Maria I.(2020). Diagnostic performance of diffusion and perfusion MRI in differentiating high from low-grade meningiomas: A systematic review and meta-analysis. Clin Neurol Neurosurg, 190(undefined), 105643. doi:10.1016/j.clineuro.2019.105643
- Poillet-Perez Laura., White Eileen.(2019). Role of tumor and host autophagy in cancer metabolism. Genes Dev, 33(null), 610-619. doi:10.1101/gad.325514.119
- Shintani Takahiro., Klionsky Daniel J.(2004). Autophagy in health and disease: a double-edged sword. Science, 306(5698), 990-5. doi:10.1126/science.1099993
- Ichimiya Tadashi., Yamakawa Tsukasa., Hirano Takehiro., Yokoyama Yoshihiro., Hayashi Yuki., Hirayama Daisuke., Wagatsuma Kohei., Itoi Takao., Nakase Hiroshi.(2020). Autophagy and Autophagy-Related Diseases: A Review. Int J Mol Sci, 21(23), undefined. doi:10.3390/ijms21238974
- Mawrin Christian., Perry Arie.(2010). Pathological classification and molecular genetics of meningiomas. J Neurooncol, 99(3), 379-91. doi:10.1007/s11060-010-0342-2
- Barthélemy Ernest Joseph., Sarkiss Christopher A., Lee James., Shrivastava Raj K.(2016). The historical origin of the term "meningioma" and the rise of nationalistic neurosurgery. J Neurosurg, 125(5), 1283-1290. doi:10.3171/2015.10.JNS15877
- Qu BQ, Mi RF, Du Jiang, Zhang Qi.(2019). Observation of ultrastructure and histological morphology
- of glioma in 39 cases. Chinese Journal of Clinicians.47(05):63-65.
- Langford L A.(1996). Central nervous system neoplasms: indications for electron microscopy. Ultrastruct Pathol, 20(1), 35-46. doi:10.3109/01913129609023236
- Song Shuling., Tan Jin., Miao Yuyang., Li Mengmeng., Zhang Qiang.(2017). Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress. J Cell Physiol, 232(11), 2977-2984. doi:10.1002/jcp.25785
- Kimmelman Alec C., White Eileen.(2017). Autophagy and Tumor Metabolism. Cell Metab, 25(5), 1037-1043. doi:10.1016/j.cmet.2017.04.004
- Saha Sarbari., Panigrahi Debasna P., Patil Shankargouda., Bhutia Sujit K.(2018). Autophagy in health and disease: A comprehensive review. Biomed Pharmacother, 104(undefined), 485-495. doi:10.1016/j.biopha.2018.05.007
- White Eileen.(2015). The role for autophagy in cancer. J Clin Invest, 125(1), 42-6. doi:10.1172/JCI73941
- Shaul Merav E., Fridlender Zvi G.(2021). The dual role of neutrophils in cancer. Semin Immunol, 57(undefined), 101582. doi:10.1016/j.smim.2021.101582
- Baird M., Gallagher P J.(1989). Recurrent intracranial and spinal meningiomas: clinical and histological features. Clin Neuropathol, 8(1), 41-4.
- Jiang Chunxue., Zhao Xiaodi., Jeong Taejoo., Kang Ju Young., Park Jae Hyeon., Kim In Su., Kim Hyung Sik.(2022). Novel Specific Pyruvate Kinase M2 Inhibitor, Compound 3h, Induces Apoptosis and Autophagy through Suppressing Akt/mTOR Signaling Pathway in LNCaP Cells. Cancers (Basel), 15(1), undefined. doi:10.3390/cancers15010265
- Sun Yanan., Wang Huihui., Qu Taiqi., Luo Junjie., An Peng., Ren Fazheng., Luo Yongting., Li Yixuan.(2023). mTORC2: a multifaceted regulator of autophagy. Cell Commun Signal, 21(1), 4. doi:10.1186/s12964-022-00859-7
- Wu Shuhua., Sun Chenbo., Tian Dong., Li Yangyang., Gao Xiangqian., He Shuang., Li Tangyue.(2015). Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. Int J Clin Exp Pathol, 8(4), 3882-91.
- Laplante Mathieu., Sabatini David M.(2012). mTOR signaling in growth control and disease. Cell, 149(2), 274-93. doi:10.1016/j.cell.2012.03.017
- Zheng Zilong., Yan Guokai., Li Xiuzhi., Fei Yuke., Sun Lingling., Yu Haonan., Niu Yaorong., Gao Weihua., Zhong Qing., Yan Xianghua.(2022). Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis. Cell Rep, 41(12), 111850. doi:10.1016/j.celrep.2022.111850
- Yang Lichao., Cheng Xiaojing., Shi Wei., Li Hui., Zhang Qi., Huang Shiping., Huang Xuejing., Wen Sha., Gan Ji., Liao Zhouxiang., Sun Junming., Liang Jinning., Ouyang Yiqiang., He Min.(2022). Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation. Nutrients, 14(17), undefined. doi:10.3390/nu14173600
- Rebchuk Alexander D., Chaharyn Bradley M., Alam Armaghan., Hounjet Celine D., Gooderham Peter A., Yip Stephen., Makarenko Serge.(2022). The impact of brain invasion criteria on the incidence and distribution of WHO grade 1, 2, and 3 meningiomas. Neuro Oncol, 24(9), 1524-1532. doi:10.1093/neuonc/noac032
- Brokinkel Benjamin., Hess Katharina., Mawrin Christian.(2017). Brain invasion in meningiomas-clinical considerations and impact of neuropathological evaluation: a systematic review. Neuro Oncol, 19(10), 1298-1307. doi:10.1093/neuonc/nox071
- Phonwijit Luckchai., Khawprapa Cheewin., Sitthinamsuwan Bunpot.(2017). Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. World Neurosurg, 107(undefined), 698-705. doi:10.1016/j.wneu.2017.08.057
- Duntze J., Metellus P., Litre C-F., Eap C., Theret E., Colin P., Peruzzi P., Rousseaux P.(2012). [Management of WHO grade II and II meningiomas: retrospective study of surgical series of 36 cases at a single institution]. Neurochirurgie, 58(5), 275-81. doi:10.1016/j.neuchi.2012.01.006
- Marciscano Ariel E., Stemmer-Rachamimov Anat O., Niemierko Andrzej., Larvie Mykol., Curry William T., Barker Fred G., Martuza Robert L., McGuone Declan., Oh Kevin S., Loeffler Jay S., Shih Helen A.(2016). Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. J Neurosurg, 124(1), 106-14. doi:10.3171/2015.1.JNS142228
- Karabagli Pinar., Karabagli Hakan., Mavi Zekiye., Demir Fatih., Ozkeles Eylem Yagmur.(2020). Histopathological and Clinical Features as Prognostic Factors of Atypical Meningiomas. Turk Neurosurg, 30(5), 746-575. doi:10.5137/1019-5149.JTN.31161-20.1
- Streckert Eileen Maria Susanne., Hess Katharina., Sporns Peter B., Adeli Alborz., Brokinkel Caroline., Kriz Jan., Holling Markus., Eich Hans Theodor., Paulus Werner., Spille Dorothee Cäcilia., van Eck Albertus T C J., Raleigh David R., McDermott Michael W., Stummer Walter., Brokinkel Benjamin.(2019). Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas. Acta Neurochir (Wien), 161(8), 1647-1656. doi:10.1007/s00701-019-03956-8
How to Cite
Zhang, Qi, et al. “Role and Mechanism of Autophagy in the Occurrence and Development of Meningothelial Meningioma”. Human Brain, vol. 2, no. 1, Jan. 2023, doi:10.37819/hb.002.001.0251.
Article Details
Most Read This Month
License
Copyright (c) 2023 Qi Zhang, Chao Hu, Yanjiao He, Guilin Li
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
