Skip to main content Skip to main navigation menu Skip to site footer

Role and mechanism of autophagy in the occurrence and development of meningothelial meningioma

  • Qi Zhang
  • Chao Hu
  • Yanjiao He
  • Guilin Li

Abstract

This paper aims to investigate the role and mechanism of autophagy in meningioma. A total of 182 meningiomas which diagnosed in the ultrastructural pathology department of Beijing Neurosurgical Institute, Beijing Tiantan Hospital from 1993 to 2021. Light microscope, electron microscope, western blotting and immunohistochemical staining were used. 182 meningiomas, 104 males and 78 females. There were 174 WHO grade 1 benign meningiomas, including 62 meningothelial types, 39 fibrous type, 58 transitional types, 15 angiomatous types, 6 WHO grade 2 cases, including 4 clear cell types and 2 atypical types, 2 WHO grade 3 anaplastic types. Transmission electron microscopy (TEM) showed that the incidence of autophagosomes as a high expression in 27 cases, most of which were meningothelial meningiomas. Immunohistochemical markers EMA, PR, Vimentin, SSTR-2, Ki67, and CD34 were positively expressed in most of the tumors, GFAP, S-100, desmin, C-erbB-2 expression were negative. Western blotting was used to detect the up-regulated proteins of LC3, Beclin1, and down-regulated proteins of Bax, Caspase3, mTOR, PI3K, Akt, S6 and 4EBP1in meningothelial meningiomas compared with the none –meningothelial control group.Autophagy is induced by down-regulating PI3K/Akt/mTOR signaling pathway molecules in meningothelial meningiomas, which can inhibit tumor apoptosis and promote tumorigenesis.

Section

References

  1. Vernooij Meike W., Ikram M Arfan., Tanghe Hervé L., Vincent Arnaud J P E., Hofman Albert., Krestin Gabriel P., Niessen Wiro J., Breteler Monique M B., van der Lugt Aad.(2007). Incidental findings on brain MRI in the general population. N Engl J Med, 357(18), 1821-8. doi:10.1056/NEJMoa070972
  2. Goldbrunner Roland., Stavrinou Pantelis., Jenkinson Michael D., Sahm Felix., Mawrin Christian., Weber Damien C., Preusser Matthias., Minniti Giuseppe., Lund-Johansen Morten., Lefranc Florence., Houdart Emanuel., Sallabanda Kita., Le Rhun Emilie., Nieuwenhuizen David., Tabatabai Ghazaleh., Soffietti Riccardo., Weller Michael.(2021). EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol, 23(11), 1821-1834. doi:10.1093/neuonc/noab150
  3. Huang Raymond Y., Bi Wenya Linda., Griffith Brent., Kaufmann Timothy J., la Fougère Christian., Schmidt Nils Ole., Tonn Jöerg C., Vogelbaum Michael A., Wen Patrick Y., Aldape Kenneth., Nassiri Farshad., Zadeh Gelareh., Dunn Ian F., International Consortium on Meningiomas.(2019). Imaging and diagnostic advances for intracranial meningiomas. Neuro Oncol, 21(null), i44-i61. doi:10.1093/neuonc/noy143
  4. Fountain Daniel M., Soon Wai Cheong., Matys Tomasz., Guilfoyle Mathew R., Kirollos Ramez., Santarius Thomas.(2017). Volumetric growth rates of meningioma and its correlation with histological diagnosis and clinical outcome: a systematic review. Acta Neurochir (Wien), 159(3), 435-445. doi:10.1007/s00701-016-3071-2
  5. Nakasu Satoshi., Nakasu Yoko.(2020). Natural History of Meningiomas: Review with Meta-analyses. Neurol Med Chir (Tokyo), 60(3), 109-120. doi:10.2176/nmc.ra.2019-0213
  6. Siempis Timoleon., Tsakiris Charalampos., Alexiou George A., Xydis Vassileios G., Voulgaris Spyridon., Argyropoulou Maria I.(2020). Diagnostic performance of diffusion and perfusion MRI in differentiating high from low-grade meningiomas: A systematic review and meta-analysis. Clin Neurol Neurosurg, 190(undefined), 105643. doi:10.1016/j.clineuro.2019.105643
  7. Poillet-Perez Laura., White Eileen.(2019). Role of tumor and host autophagy in cancer metabolism. Genes Dev, 33(null), 610-619. doi:10.1101/gad.325514.119
  8. Shintani Takahiro., Klionsky Daniel J.(2004). Autophagy in health and disease: a double-edged sword. Science, 306(5698), 990-5. doi:10.1126/science.1099993
  9. Ichimiya Tadashi., Yamakawa Tsukasa., Hirano Takehiro., Yokoyama Yoshihiro., Hayashi Yuki., Hirayama Daisuke., Wagatsuma Kohei., Itoi Takao., Nakase Hiroshi.(2020). Autophagy and Autophagy-Related Diseases: A Review. Int J Mol Sci, 21(23), undefined. doi:10.3390/ijms21238974
  10. Mawrin Christian., Perry Arie.(2010). Pathological classification and molecular genetics of meningiomas. J Neurooncol, 99(3), 379-91. doi:10.1007/s11060-010-0342-2
  11. Barthélemy Ernest Joseph., Sarkiss Christopher A., Lee James., Shrivastava Raj K.(2016). The historical origin of the term "meningioma" and the rise of nationalistic neurosurgery. J Neurosurg, 125(5), 1283-1290. doi:10.3171/2015.10.JNS15877
  12. Qu BQ, Mi RF, Du Jiang, Zhang Qi.(2019). Observation of ultrastructure and histological morphology
  13. of glioma in 39 cases. Chinese Journal of Clinicians.47(05):63-65.
  14. Langford L A.(1996). Central nervous system neoplasms: indications for electron microscopy. Ultrastruct Pathol, 20(1), 35-46. doi:10.3109/01913129609023236
  15. Song Shuling., Tan Jin., Miao Yuyang., Li Mengmeng., Zhang Qiang.(2017). Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress. J Cell Physiol, 232(11), 2977-2984. doi:10.1002/jcp.25785
  16. Kimmelman Alec C., White Eileen.(2017). Autophagy and Tumor Metabolism. Cell Metab, 25(5), 1037-1043. doi:10.1016/j.cmet.2017.04.004
  17. Saha Sarbari., Panigrahi Debasna P., Patil Shankargouda., Bhutia Sujit K.(2018). Autophagy in health and disease: A comprehensive review. Biomed Pharmacother, 104(undefined), 485-495. doi:10.1016/j.biopha.2018.05.007
  18. White Eileen.(2015). The role for autophagy in cancer. J Clin Invest, 125(1), 42-6. doi:10.1172/JCI73941
  19. Shaul Merav E., Fridlender Zvi G.(2021). The dual role of neutrophils in cancer. Semin Immunol, 57(undefined), 101582. doi:10.1016/j.smim.2021.101582
  20. Baird M., Gallagher P J.(1989). Recurrent intracranial and spinal meningiomas: clinical and histological features. Clin Neuropathol, 8(1), 41-4.
  21. Jiang Chunxue., Zhao Xiaodi., Jeong Taejoo., Kang Ju Young., Park Jae Hyeon., Kim In Su., Kim Hyung Sik.(2022). Novel Specific Pyruvate Kinase M2 Inhibitor, Compound 3h, Induces Apoptosis and Autophagy through Suppressing Akt/mTOR Signaling Pathway in LNCaP Cells. Cancers (Basel), 15(1), undefined. doi:10.3390/cancers15010265
  22. Sun Yanan., Wang Huihui., Qu Taiqi., Luo Junjie., An Peng., Ren Fazheng., Luo Yongting., Li Yixuan.(2023). mTORC2: a multifaceted regulator of autophagy. Cell Commun Signal, 21(1), 4. doi:10.1186/s12964-022-00859-7
  23. Wu Shuhua., Sun Chenbo., Tian Dong., Li Yangyang., Gao Xiangqian., He Shuang., Li Tangyue.(2015). Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. Int J Clin Exp Pathol, 8(4), 3882-91.
  24. Laplante Mathieu., Sabatini David M.(2012). mTOR signaling in growth control and disease. Cell, 149(2), 274-93. doi:10.1016/j.cell.2012.03.017
  25. Zheng Zilong., Yan Guokai., Li Xiuzhi., Fei Yuke., Sun Lingling., Yu Haonan., Niu Yaorong., Gao Weihua., Zhong Qing., Yan Xianghua.(2022). Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis. Cell Rep, 41(12), 111850. doi:10.1016/j.celrep.2022.111850
  26. Yang Lichao., Cheng Xiaojing., Shi Wei., Li Hui., Zhang Qi., Huang Shiping., Huang Xuejing., Wen Sha., Gan Ji., Liao Zhouxiang., Sun Junming., Liang Jinning., Ouyang Yiqiang., He Min.(2022). Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation. Nutrients, 14(17), undefined. doi:10.3390/nu14173600
  27. Rebchuk Alexander D., Chaharyn Bradley M., Alam Armaghan., Hounjet Celine D., Gooderham Peter A., Yip Stephen., Makarenko Serge.(2022). The impact of brain invasion criteria on the incidence and distribution of WHO grade 1, 2, and 3 meningiomas. Neuro Oncol, 24(9), 1524-1532. doi:10.1093/neuonc/noac032
  28. Brokinkel Benjamin., Hess Katharina., Mawrin Christian.(2017). Brain invasion in meningiomas-clinical considerations and impact of neuropathological evaluation: a systematic review. Neuro Oncol, 19(10), 1298-1307. doi:10.1093/neuonc/nox071
  29. Phonwijit Luckchai., Khawprapa Cheewin., Sitthinamsuwan Bunpot.(2017). Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. World Neurosurg, 107(undefined), 698-705. doi:10.1016/j.wneu.2017.08.057
  30. Duntze J., Metellus P., Litre C-F., Eap C., Theret E., Colin P., Peruzzi P., Rousseaux P.(2012). [Management of WHO grade II and II meningiomas: retrospective study of surgical series of 36 cases at a single institution]. Neurochirurgie, 58(5), 275-81. doi:10.1016/j.neuchi.2012.01.006
  31. Marciscano Ariel E., Stemmer-Rachamimov Anat O., Niemierko Andrzej., Larvie Mykol., Curry William T., Barker Fred G., Martuza Robert L., McGuone Declan., Oh Kevin S., Loeffler Jay S., Shih Helen A.(2016). Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. J Neurosurg, 124(1), 106-14. doi:10.3171/2015.1.JNS142228
  32. Karabagli Pinar., Karabagli Hakan., Mavi Zekiye., Demir Fatih., Ozkeles Eylem Yagmur.(2020). Histopathological and Clinical Features as Prognostic Factors of Atypical Meningiomas. Turk Neurosurg, 30(5), 746-575. doi:10.5137/1019-5149.JTN.31161-20.1
  33. Streckert Eileen Maria Susanne., Hess Katharina., Sporns Peter B., Adeli Alborz., Brokinkel Caroline., Kriz Jan., Holling Markus., Eich Hans Theodor., Paulus Werner., Spille Dorothee Cäcilia., van Eck Albertus T C J., Raleigh David R., McDermott Michael W., Stummer Walter., Brokinkel Benjamin.(2019). Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas. Acta Neurochir (Wien), 161(8), 1647-1656. doi:10.1007/s00701-019-03956-8

How to Cite

Zhang, Q. ., C. . Hu, Y. . He, and G. . Li. “Role and Mechanism of Autophagy in the Occurrence and Development of Meningothelial Meningioma”. Human Brain, vol. 2, no. 1, Jan. 2023, doi:10.37819/hb.002.001.0251.

HTML
37

Total
24

Share

Downloads

Article Details

Most Read This Month

License

Copyright (c) 2023 Qi Zhang, Chao Hu, Yanjiao He, Guilin Li

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.