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    Reconstructing Structure and Function Post Spinal Cord Injury by Facilitating Novel Integration Therapy and Neuromodulation

    • Qiqi Yang
    • Chenyuan Ding
    • Fengzeng Jian
    • Zan Chen
    • Zhuofan Xu
    • Wanru Duan


    Abstract

    Spinal cord injury (SCI) has been a research hotspot for its poor prognosis and limited effects in current treatment methods. Consistent hostile responses in damaged regions and functional incapabilities can lead to major complications. Most approaches focus on either structural or functional reconstruction. For restoring function, facilitating innate neuroplasticity and neuromodulation showed promising potentials, including rehabilitation therapy and various forms of electrical stimulation, examples include epidural electrical stimulation (EES), functional electrical stimulation (FES), transcutaneous electrical neural stimulation (TENS), and deep brain stimulation (DBS). Recent advances in treatments for SCI include integrating conventional methods and installing interfaces, such as brain-computer interface (BCI) and brain-spine interface (BSI).

    Keywords: Spinal Cord Injury Neuromodulation Electrical Stimulation Rehabilitation Therapy Functional Reconstruction
    Section

    References

    1. [1]. WHO Spinal Cord Injury. 2024.
    2. [2]. Safdarian, M., et al., Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology, 2023. 22(11): p. 1026-1047.
    3. [3]. Crispo, J.A.G., L.K. Kuramoto and J.J. Cragg, Global burden of spinal cord injury: future directions. The Lancet Neurology, 2023. 22(11): p. 976-978.
    4. [4]. Courtine, G. and M.V. Sofroniew, Spinal cord repair: advances in biology and technology. Nature Medicine, 2019. 25(6): p. 898-908.
    5. [5]. Zheng, B. and M.H. Tuszynski, Regulation of axonal regeneration after mammalian spinal cord injury. Nature Reviews Molecular Cell Biology, 2023. 24(6): p. 396-413.
    6. [6]. Hellenbrand, D.J., et al., Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration. Journal of Neuroinflammation, 2021. 18(1): p. 284.
    7. [7]. Anjum, A., et al., Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms. International Journal of Molecular Sciences, 2020. 21(20): p. 7533.
    8. [8]. Hu, X., et al., Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther, 2023. 8(1): p. 245.
    9. [9]. Sunshine, M.D., et al., Oxygen therapy attenuates neuroinflammation after spinal cord injury. Journal of Neuroinflammation, 2023. 20(1): p. 303.
    10. [10]. Chio, J.C.T., et al., Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives. Experimental Neurology, 2021. 341: p. 113704.
    11. [11]. Chen, K., et al., Biomaterial-based regenerative therapeutic strategies for spinal cord injury. NPG Asia Materials, 2024. 16(1): p. 5.
    12. [12]. Sámano, C. and A. Nistri, Mechanism of Neuroprotection Against Experimental Spinal Cord Injury by Riluzole or Methylprednisolone. Neurochemical Research, 2019. 44(1): p. 200-213.
    13. [13]. Fehlings, M.G., et al., A Clinical Practice Guideline for the Management of Acute Spinal Cord Injury: Introduction, Rationale, and Scope. Global Spine Journal, 2017. 7(3_suppl): p. 84S-94S.
    14. [14]. Li, Y., et al., Microglia-organized scar-free spinal cord repair in neonatal mice. Nature, 2020. 587(7835): p. 613-618.
    15. [15]. Trumbower, R.D., et al., Caffeine Enhances Intermittent Hypoxia-Induced Gains in Walking Function for People with Chronic Spinal Cord Injury. Journal of Neurotrauma, 2022. 39(23-24): p. 1756-1763.
    16. [16]. Irrera, N., et al., Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates WNT/β-CATENIN Driven Neurogenesis in Spinal Cord Injury. Frontiers in Pharmacology, 2018. 9.
    17. [17]. Paterniti, I., et al., Selective adenosine A2Areceptor agonists and antagonists protect against spinal cord injury through peripheral and central effects. Journal of Neuroinflammation, 2011. 8(1): p. 31.
    18. [18]. Chow, D.S., et al., Riluzole in Spinal Cord Injury Study (RISCIS)–Pharmacokinetic (PK) Sub-Study: An Analysis of Pharmacokinetics, Pharmacodynamics, and Impact on Axonal Degradation of Riluzole in Patients With Traumatic Cervical Spinal Cord Injury Enrolled in the RISCIS Phase III Randomized Controlled Trial. Journal of Neurotrauma, 2023. 40(17-18): p. 1889-1906.
    19. [19]. Schwartz, G. and M.G. Fehlings, Secondary injury mechanisms of spinal cord trauma: a novel therapeutic
    20. approach for the management of secondary pathophysiology with the sod
    21. ium channel blocker riluzole. Progress in brain research, 2002. 137: p. 177-90.
    22. [20]. Chen, H., et al., N-methyl-D-aspartate receptor-mediated spinal cord ischemia-reperfusion injury and its protective mechanism. Folia Neuropathologica, 2022. 60(3): p. 308-315.
    23. [21]. Fehlings, M.G., et al., Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial. Journal of Neurotrauma, 2023. 40(17-18): p. 1878-1888.
    24. [22]. Poplawski, G.H.D., et al., Injured adult neurons regress to an embryonic transcriptional growth state. Nature, 2020. 581(7806): p. 77-82.
    25. [23]. Zhou, J., et al., Brain-wide correspondence of neuronal epigenomics and distant projections. Nature, 2023. 624(7991): p. 355-365.
    26. [24]. Anderson, M.A., et al., Natural and targeted circuit reorganization after spinal cord injury. Nature Neuroscience, 2022. 25(12): p. 1584-1596.
    27. [25]. Squair, J.W., et al., Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science, 2023. 381(6664): p. 1338-1345.
    28. [26]. Hall, A., et al., Chapter Three - Cell transplantation to repair the injured spinal cord, in International Review of Neurobiology, E.L. Lane, C.J.G. Drew and M.J. Lelos, E.L. Lane, C.J.G. Drew and M.J. Lelos^Editors. 2022, Academic Press. p. 79-158.
    29. [27]. Liu, W., et al., Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury. Stem Cell Research & Therapy, 2021. 12(1): p. 102.
    30. [28]. Li, Y., P. Shen and B. Wang, Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy. Neural Regeneration Research, 2021. 16(8): p. 1500.
    31. [29]. Wu, W., et al., Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury. ACS Nano, 2023. 17(4): p. 3818-3837.
    32. [30]. Hosseini, S.M., B. Borys and S. Karimi-Abdolrezaee, Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances. Brain, 2024. 147(3): p. 766-793.
    33. [31]. Li, J., et al., Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics, 2023. 13(12): p. 3966-3987.
    34. [32]. Kaplan, B. and S. Levenberg, The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review, in International Journal of Molecular Sciences. 2022.
    35. [33]. Tang, F., et al., Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Science China Life Sciences, 2022. 65(5): p. 909-926.
    36. [34]. Koffler, J., et al., Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nature Medicine, 2019. 25(2): p. 263-269.
    37. [35]. Hutchinson, J.M. and L.G. Isaacson, Elimination of microglia in mouse spinal cord alters the retrograde CNS plasticity observed following peripheral axon injury. Brain Research, 2019. 1721: p. 146328.
    38. [36]. Mosberger, A.C., et al., Axotomized Corticospinal Neurons Increase Supra-Lesional Innervation and Remain Crucial for Skilled Reaching after Bilateral Pyramidotomy. Cerebral Cortex, 2017. 28(2): p. 625-643.
    39. [37]. Qian, J., et al., Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice. Journal of Neurotrauma, 2019. 36(3): p. 485-499.
    40. [38]. Xing, Y. and Y. Bai, A Review of Exercise-Induced Neuroplasticity in Ischemic Stroke: Pathology and Mechanisms. Molecular Neurobiology, 2020. 57(10): p. 4218-4231.
    41. [39]. Edgerton, V.R., et al., PLASTICITY OF THE SPINAL NEURAL CIRCUITRY AFTER INJURY. Annual Review of Neuroscience, 2004. 27(1): p. 145-167.
    42. [40]. Hötting, K. and B. Röder, Beneficial effects of physical exercise on neuroplasticity and cognition. Neuroscience & Biobehavioral Reviews, 2013. 37(9): p. 2243-2257.
    43. [41]. Ly, C., et al., Psychedelics Promote Structural and Functional Neural Plasticity. Cell Reports, 2018. 23(11): p. 3170-3182.
    44. [42]. Jeon, S.M., et al., SKIN REINNERVATION BY COLLATERAL SPROUTING FOLLOWING SPARED NERVE INJURY IN MICE. bioRxiv, 2023: p. 2023.09.12.557420.
    45. [43]. Son, Y. and W.J. Thompson, Nerve sprouting in muscle is induced and guided by processes extended by schwann cells. Neuron, 1995. 14(1): p. 133-141.
    46. [44]. Magee, J.C. and C. Grienberger, Synaptic Plasticity Forms and Functions. Annual Review of Neuroscience, 2020. 43(1): p. 95-117.
    47. [45]. Markram, H., et al., Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs. Science, 1997. 275(5297): p. 213-215.
    48. [46]. Monje, M., Myelin Plasticity and Nervous System Function. Annual review of neuroscience, 2018. 41: p. 61-76.
    49. [47]. Calderone, A., et al., Brain Plasticity in Patients with Spinal Cord Injuries: A Systematic Review. International Journal of Molecular Sciences, 2024. 25(4): p. 2224.
    50. [48]. Li, Z., et al., Research advances of biomaterials-based microenvironment-regulation therapies for repair and regeneration of spinal cord injury. Biomedical Materials, 2021. 16(5): p. 052002.
    51. [49]. López-Larraz, E., et al., Control of an Ambulatory Exoskeleton with a Brain–Machine Interface for Spinal Cord Injury Gait Rehabilitation. Frontiers in Neuroscience, 2016. 10.
    52. [50]. Ajiboye, A.B., et al., Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. The Lancet, 2017. 389(10081): p. 1821-1830.
    53. [51]. Hoffman, H., et al., Rehabilitation of hand function after spinal cord injury using a novel handgrip device: a pilot study. Journal of NeuroEngineering and Rehabilitation, 2017. 14(1): p. 22.
    54. [52]. Akkurt, H., et al., The effects of upper extremity aerobic exercise in patients with spinal cord injury: a randomized controlled study. European Journal of Physical and Rehabilitation Medicine, 2017. 53(2): p. 219-227.
    55. [53]. Edwards, D.J., et al., Walking improvement in chronic incomplete spinal cord injury with exoskeleton robotic training (WISE): a randomized controlled trial. Spinal Cord, 2022. 60(6): p. 522-532.
    56. [54]. Rowald, A., et al., Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nature Medicine, 2022. 28(2): p. 260-271.
    57. [55]. Nicolelis, M.A.L., et al., Training with noninvasive brain–machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study. Scientific Reports, 2022. 12(1): p. 20545.
    58. [56]. Mitchell, P., et al., Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients. JAMA Neurology, 2023. 80(3): p. 270.
    59. [57]. Jo, H.J., et al., Multisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury. Annals of Neurology, 2023. 93(6): p. 1198-1213.
    60. [58]. Lorach, H., et al., Walking naturally after spinal cord injury using a brain–spine interface. Nature, 2023. 618(7963): p. 126-133.
    61. [59]. Moritz, C., et al., Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial. Nature Medicine, 2024. 30(5): p. 1276-1283.
    62. [60]. Comino-Suárez, N., et al., Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord injury: a double-blind randomized controlled clinical trial. Journal of NeuroEngineering and Rehabilitation, 2025. 22(1): p. 15.
    63. [61]. Sandrow-Feinberg, H.R. and J.D. Houlé, Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation. Brain Research, 2015. 1619: p. 12-21.
    64. [62]. Spine Injury Best Practices Guidelines. 2022, American College of Surgeons Trauma Quality Programs (ACS TQP).
    65. [63]. Giangregorio, L. and N. McCartney, Bone Loss and Muscle Atrophy in Spinal Cord Injury: Epidemiology, Fracture Prediction, and Rehabilitation Strategies. The Journal of Spinal Cord Medicine, 2016. 29(5): p. 489-500.
    66. [64]. Ding, S., et al., An Overview of Muscle Atrophy. Advances in experimental medicine and biology, 2018. 1088: p. 3-19.
    67. [65]. Carraro, U., et al., To Contrast and Reverse Skeletal Muscle Atrophy by Full-Body In-Bed Gy
    68. m, a Mandatory Lifestyle for Older Olds and Borderline Mobility-Impair
    69. ed Persons. Advances in experimental medicine and biology, 2018. 1088: p. 549-560.
    70. [66]. Gordon, T. and J. Mao, Muscle Atrophy and Procedures for Training After Spinal Cord Injury. Physical Therapy, 1994. 74(1): p. 50-60.
    71. [67]. Atkins, K.D. and C.S. Bickel, Effects of functional electrical stimulation on muscle health after spinal cord injury. Current Opinion in Pharmacology, 2021. 60: p. 226-231.
    72. [68]. Chandrasekaran, S., et al., Electrical stimulation and denervated muscles after spinal cord injury. Neural Regeneration Research, 2020. 15(8): p. 1397.
    73. [69]. Thomaz, S.R., et al., Effect of electrical stimulation on muscle atrophy and spasticity in patients with spinal cord injury – a systematic review with meta-analysis. Spinal Cord, 2019. 57(4): p. 258-266.
    74. [70]. Otzel, D.M., et al., Pharmacologic approaches to prevent skeletal muscle atrophy after spinal cord injury. Current Opinion in Pharmacology, 2021. 60: p. 193-199.
    75. [71]. Kok, H.J., et al., Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats. Journal of Cachexia, Sarcopenia and Muscle, 2024. 15(4): p. 1309-1323.
    76. [72]. Faw, T.D., et al., Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury. Experimental Neurology, 2021. 346: p. 113853.
    77. [73]. Dunlop, S.A., Activity-dependent plasticity: implications for recovery after spinal cord injury. Trends in Neurosciences, 2008. 31(8): p. 410-418.
    78. [74]. Duan, R., et al., Clinical Benefit of Rehabilitation Training in Spinal Cord Injury. Spine, 2021. 46(6): p. E398-E410.
    79. [75]. Mehrholz, J., et al., Electromechanical-assisted training for walking after stroke. Cochrane Database of Systematic Reviews, 2020. 2020(10).
    80. [76]. Gil-Agudo, Á., et al., Exoskeleton-based training improves walking independence in incomplete spinal cord injury patients: results from a randomized controlled trial. Journal of NeuroEngineering and Rehabilitation, 2023. 20(1): p. 36.
    81. [77]. Rodríguez-Fernández, A., J. Lobo-Prat and J.M. Font-Llagunes, Systematic review on wearable lower-limb exoskeletons for gait training in neuromuscular impairments. Journal of NeuroEngineering and Rehabilitation, 2021. 18(1): p. 22.
    82. [78]. Guanziroli, E., et al., Assistive powered exoskeleton for complete spinal cord injury: correlations between walking ability and exoskeleton control. European Journal of Physical and Rehabilitation Medicine, 2019. 55(2): p. 209-216.
    83. [79]. Louie, D.R., J.J. Eng and T. Lam, Gait speed using powered robotic exoskeletons after spinal cord injury: a systematic review and correlational study. Journal of NeuroEngineering and Rehabilitation, 2015. 12(1): p. 82.
    84. [80]. Nam, K.Y., et al., Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: a systematic review. Journal of NeuroEngineering and Rehabilitation, 2017. 14(1): p. 24.
    85. [81]. Swank, C., et al., Foundational ingredients of robotic gait training for people with incomplete spinal cord injury during inpatient rehabilitation (FIRST): A randomized controlled trial protocol. PLOS ONE, 2022. 17(5): p. e0267013.
    86. [82]. Swank, C., et al., The utilization of an overground robotic exoskeleton for gait training during inpatient rehabilitation—single-center retrospective findings. International Journal of Rehabilitation Research, 2020. 43(3): p. 206-213.
    87. [83]. Kimura, R., et al., Development of a Rehabilitation Robot Combined with Functional Electrical Stimulation Controlled by Non-disabled Lower Extremity in Hemiplegic Gait. Progress in Rehabilitation Medicine, 2018. 3: p. n/a.
    88. [84]. Jo, H.J. and M.A. Perez, Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury. Brain, 2020. 143(5): p. 1368-1382.
    89. [85]. Miller, K.J., et al., Effect of repetitive transcranial magnetic stimulation combined with robot-assisted training on wrist muscle activation post-stroke. Clinical Neurophysiology, 2019. 130(8): p. 1271-1279.
    90. [86]. Eraifej, J., et al., Effectiveness of upper limb functional electrical stimulation after stroke for the improvement of activities of daily living and motor function: a systematic review and meta-analysis. Systematic Reviews, 2017. 6(1): p. 40.
    91. [87]. Kuwahara, W., et al., The effects of robot-assisted gait training combined with non-invasive brain stimulation on lower limb function in patients with stroke and spinal cord injury: A systematic review and meta-analysis. Frontiers in Human Neuroscience, 2022. 16: p. 969036.
    92. [88]. Karamian, B.A., et al., The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury. Journal of Orthopaedics and Traumatology, 2022. 23(1): p. 2.
    93. [89]. Zhou, K., et al., Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury. Nature Communications, 2024. 15(1): p. 619.
    94. [90]. Rabelo, M., et al., Overview of FES-Assisted Cycling Approaches and Their Benefits on Functional Rehabilitation and Muscle Atrophy, J. Xiao, J. Xiao^Editors. 2018, Springer Singapore: Singapore. p. 561-583.
    95. [91]. Singh, G., et al., Transcutaneous Spinal Stimulation From Adults to Children: A Review. Topics in Spinal Cord Injury Rehabilitation, 2023. 29(1): p. 16-32.
    96. [92]. Johnson, M.I., et al., Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS study). BMJ Open, 2022. 12(2): p. e051073.
    97. [93]. Yang, Y., et al., Efficacy of transcutaneous electrical nerve stimulation in people with pain after spinal cord injury: a meta-analysis. Spinal Cord, 2022. 60(5): p. 375-381.
    98. [94]. Inanici, F., et al., Transcutaneous Spinal Cord Stimulation Restores Hand and Arm Function After Spinal Cord Injury. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2021. 29: p. 310-319.
    99. [95]. Shapkova, E.Y., et al., Exoskeleton Walk Training in Paralyzed Individuals Benefits From Transcutaneous Lumbar Cord Tonic Electrical Stimulation. Frontiers in Neuroscience, 2020. 14: p. 416.
    100. [96]. Hariz, M. and P. Blomstedt, Deep brain stimulation for Parkinson's disease. Journal of Internal Medicine, 2022. 292(5): p. 764-778.
    101. [97]. Cho, N., et al., Hypothalamic deep brain stimulation augments walking after spinal cord injury. Nature Medicine, 2024. 30(12): p. 3676-3686.
    102. [98]. Cobo-Vicente, F., et al., Neuromuscular Electrical Stimulation Improves Muscle Strength, Biomechanics of Movement, and Functional Mobility in Children With Chronic Neurological Disorders: A Systematic Review and Meta-Analysis. Physical Therapy, 2021. 101(10).
    103. [99]. Edmond, E.C., C.J. Stagg and M.R. Turner, Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience. Journal of Neurology, Neurosurgery & Psychiatry, 2019. 90(10): p. 1131-1138.
    104. [100]. Novikov, A., et al., Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs. Biomedicines, 2024. 12(6): p. 1162.
    105. [101]. Angrick, M., et al., Online speech synthesis using a chronically implanted brain–computer interface in an individual with ALS. Scientific Reports, 2024. 14(1): p. 9617.
    106. [102]. Rahman, M., et al., A Review on the Pathophysiology and Management of Anterior Spinal Artery Syndrome. Journal of Spine Research and Surgery, 2020. 02(04).
    107. [103]. DesRochers, J., et al., Rehabilitative Management of the Anterior Spinal Artery Syndrome (ASAS) Patient. Journal of Spine Research and Surgery, 2023. 05(04).
    108. [104]. Wang, J., et al., Flexible Electrodes for Brain–Computer Interface System. Advanced Materials, 2023. 35(47): p. 2211012.
    109. [105]. Naddaf, M. and L. Drew, Second brain implant by Elon Musk’s Neuralink: will it fare better than the first? Nature, 2024. 632(8025): p. 481-482.
    110. [106]. Sun, Y., et al., Signal acquisition of brain–computer interfaces: A medical-engineering crossover perspective review. Fundamental Research, 2024.
    111. [107]. Pandarinath, C. and S.J. Bensmaia, The science and engineering behind sensitized brain-controlled bionic hands. Physiological Reviews, 2022. 102(2): p. 551-604.
    112. [108]. Lai, C., et al., Volitional activation of remote place representations with a hippocampal brain–machine interface. Science, 2023. 382(6670): p. 566-573.
    113. Table References
    114. [1]. López-Larraz, E., et al., Control of an Ambulatory Exoskeleton with a Brain–Machine Interface for Spinal Cord Injury Gait Rehabilitation. Frontiers in Neuroscience, 2016. 10.
    115. [2]. Ajiboye, A.B., et al., Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. The Lancet, 2017. 389(10081): p. 1821-1830.
    116. [3]. Hoffman, H., et al., Rehabilitation of hand function after spinal cord injury using a novel handgrip device: a pilot study. Journal of NeuroEngineering and Rehabilitation, 2017. 14(1): p. 22.
    117. [4]. Akkurt, H., et al., The effects of upper extremity aerobic exercise in patients with spinal cord injury: a randomized controlled study. European Journal of Physical and Rehabilitation Medicine, 2017. 53(2): p. 219-227.
    118. [5]. Edwards, D.J., et al., Walking improvement in chronic incomplete spinal cord injury with exoskeleton robotic training (WISE): a randomized controlled trial. Spinal Cord, 2022. 60(6): p. 522-532.
    119. [6]. Rowald, A., et al., Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nature Medicine, 2022. 28(2): p. 260-271.
    120. [7]. Nicolelis, M.A.L., et al., Training with noninvasive brain–machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study. Scientific Reports, 2022. 12(1): p. 20545.
    121. [8]. Mitchell, P., et al., Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients. JAMA Neurology, 2023. 80(3): p. 270.
    122. [9]. Jo, H.J., et al., Multisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury. Annals of Neurology, 2023. 93(6): p. 1198-1213.
    123. [10]. Lorach, H., et al., Walking naturally after spinal cord injury using a brain–spine interface. Nature, 2023. 618(7963): p. 126-133.
    124. [11]. Moritz, C., et al., Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial. Nature Medicine, 2024. 30(5): p. 1276-1283.
    125. [12]. Comino-Suárez, N., et al., Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord injury: a double-blind randomized controlled clinical trial. Journal of NeuroEngineering and Rehabilitation, 2025. 22(1): p. 15.

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    “Reconstructing Structure and Function Post Spinal Cord Injury by Facilitating Novel Integration Therapy and Neuromodulation”. Human Brain, vol. 3, no. 4, Mar. 2025, https://doi.org/10.37819/hb.4.2049.
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    “Reconstructing Structure and Function Post Spinal Cord Injury by Facilitating Novel Integration Therapy and Neuromodulation”. Human Brain, vol. 3, no. 4, Mar. 2025, https://doi.org/10.37819/hb.4.2049.

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