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    Preclinical Experimental Models for Human Glioma

    • Diya Zhang
    • Yunfan Li
    • Yucheng Wang
    • Rui Ju
    • Lei Guo


    Abstract

    Gliomas are one of the most common incurable brain tumors in adults with poor prognosis. Attempts at modeling human gliomas over the past decades have not only improved our knowledge of glioma biology but also boosted the development of therapeutic strategies. Despite great endeavors, gliomas are not responsive to the current tumor treatments, such as radiotherapy, chemotherapy, and immunotherapy due to their high inter- and intra-heterogenic tumor microenvironment (TME) and immune suppressive landscape. Therefore, it is significant to utilize suitable models to investigate the tumorigenesis, progression, and invasion of gliomas and evaluate potential therapies. Ideally, glioma models should fully recapitulate the genetic alterations and histological characteristics of the parental tumor, as well as reproduce the interactions between the tumor and its TME. In this review, we will discuss and compare the pros and cons of the current glioma models including traditional mouse models, established cell lines, newly 3D-cultured organoids, and 3D bioprinting glioma models in glioma pathogenesis research and therapy evaluation.

    Keywords: Glioma Glioblastoma Experimental Models
    Section

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    Zhang, Diya, et al. “Preclinical Experimental Models for Human Glioma”. Human Brain, vol. 2, no. 4, Dec. 2023, doi:10.37819/hb.4.1789.
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    DOI: https://doi.org/10.37819/hb.4.1789

    Published: 2023-12-30

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